Oligo Hyaluronan‐Coated Silica/Hydroxyapatite Degradable Nanoparticles for Targeted Cancer Treatment

Targeted Nanoparticles for Cancer Therapy

The World Health Organization (WHO) estimates that 84 million people will die of cancer between 2005-2015 [1]. According using the WHO mortality database it has been estimated the total number of cancer deaths in the European Union (EU) and in 2012 is predicted to be 1283101, of which 717398 men and 565703 women [2]. The most common types of cancer that will be diagnosed are lung (C33-C34), int...

Systemic Targeted Alpha Radiotherapy for Cancer

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

Hepatocellular carcinoma-targeted nanoparticles for cancer therapy

Nanocarriers, such as liposomes, have the potential to increase the payload of chemotherapeutic drugs while decreasing toxicity to non-target tissues; such advantageous properties can be further enhanced through surface conjugation of nanocarriers with targeting moieties. We previously reported that SP94 peptides, identified by phage display, exhibited higher binding affinity to human hepatocel...

Targeted Nanoparticles for Kidney Cancer Therapy

Nanoparticles for cancer treatment.

mediciNe & HealtH/RHode iSlaNd partICleS Can be engIneered to nanometer-size (nm) which are only 1/1,000 the width of a single human hair. Nanoparticles made of gold display strong optical absorption. A special type of gold nanoparticle called hollow gold nanoparticle has a core-shell nanostructure with unique characteristics, including small particle size (~40 nm in diameter), which is an idea...